Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway

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成果类型：

期刊论文

作者：

Zhao, Zhen-Wang;Zhang, Min;Chen, Ling-Yan;Cong, Duo;Xia, Xiao-Dan;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Ou, Xiang; Tang, Chao-Ke; Cong, Duo; Zhao, Zhen-Wang; Wang, Si-Qi; Yu, Xiao-Hua; Chen, Ling-Yan; Xia, Xiao-Dan; Zhang, Min] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Med Res Expt Ct, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Ou, Xiang] First Hosp Changsha, Dept Endocrinol, Changsha 410005, Hunan, Peoples R China.

[Dai, Xiao-Yan] Guangzhou Med Univ, Guangdong Prov Key Lab Mol Target & Clin Pharmaco, Sch Pharmaceut Sci, Guangzhou 511436, Guangdong, Peoples R China.

[Dai, Xiao-Yan] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Med Res Expt Ct, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

HSP70;Atherosclerosis;Cholesterol efflux;ABCA1;ABCG1;Reverse cholesterol transport

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ISSN：

1388-1981

年：

2018

卷：

1863

期：

页码：

806-822

DOI：

10.1016/j.bbalip.2018.04.011

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (81570408), the construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa NO. [2011]76), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0002-0002000-41, 0223-0002-0002000-42), science and technology plan project of Changsha City (KQ1602028) and the Natural Science Foundation of Hunan Province (2017JJ2286).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background and aims: Recent studies have suggested that heat shock protein 70 (HSP70) may play critical roles in cardiovascular disease. However, the effects of HSP70 on the development of atherosclerosis in apoE−/− mice remain largely unknown. This study was to investigate the role and potential mechanism of HSP70 in atherosclerosis. Methods: HSP70 was overexpressed in apoE−/− mice and THP-1-derived macrophages with lentiviral vectors. Oil Red O, hematoxylin-eosin, and Masson staining were performed to evaluate atherosclerotic plaque in ap...

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Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway

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