Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation

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成果类型：

期刊论文

作者：

Yu, Zi-Jian;Luo, Hui-Hui;Shang, Zeng-Fu;Guan, Hua;Xiao, Bei-Bei;...

通讯作者：

Huang, Bo;Zhou, Ping-Kun

作者机构：

[Yu, Zi-Jian] Univ South China, Affiliated Hosp 1, Dept Hepatobiliary Surg, Hengyang 421001, Hunan, Peoples R China.

[Huang, Bo; Luo, Hui-Hui; Zhou, Ping-Kun] Univ South China, Coll Publ Hlth, Inst Environm Med & Radiat Hlth, Hengyang 421001, Hunan, Peoples R China.

[Guan, Hua; Wang, Yu; Luo, Hui-Hui; Liu, Xiao-Dan; Zhou, Ping-Kun] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol BKLRB, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China.

[Shang, Zeng-Fu; Xiao, Bei-Bei] Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Sch Radiat Med & Protect,Med Coll, Suzhou 215123, Jiangsu, Peoples R China.

通讯机构：

[Huang, Bo] U

[Zhou, Ping-Kun] B

Univ South China, Coll Publ Hlth, Inst Environm Med & Radiat Hlth, Hengyang 421001, Hunan, Peoples R China.

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol BKLRB, Dept Radiat Toxicol & Oncol, Beijing 100850, Peoples R China.

语种：

英文

关键词：

4E-BP1;PI3K kinase

期刊：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES

ISSN：

1449-1907

年：

2017

卷：

期：

页码：

452-461

DOI：

10.7150/ijms.18329

基金类别：

National Key Basic Research Program (973 Program) of MOST, China [2015CB910601]; Chinese National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81272994, 81530085]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Objectives: 4E-BP1 is a family member of eIF4E binding proteins (4E-BPs) which act as the suppressors of cap-dependent translation of RNA via competitively associating with cap-bound eIF4E. RNA translation regulation is an important manner to control the cellular responses to a series of stress conditions such as ionizing radiation (IR)-induced DNA damage response and cell cycle controlling. This study aimed to determine the mechanism of 4E-BP1 stabilization and its potential downstream target(s) in the response to IR. Methods: PI3Ks kinase inhibitors were used to determine the signaling contr...

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Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation

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