Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Peng;Li, Chunxiang;Ye, Dong mei;Yu, Kenan;Li, Yuxuan;...

通讯作者：

Zhan, Zhiwei;Yi, Shuijing

作者机构：

[Wu, Peng; Zhan, Zhiwei] Hengyang Maternal & Child Hlth Hosp, Dept Crit Care Med, Hengyang 421001, Hunan, Peoples R China.

[Li, Chunxiang; Xu, Gaoshen; Zhan, Zhiwei] Yueyang Maternal & Child Hlth Hosp, Yueyang 414000, Hunan, Peoples R China.

[Li, Chunxiang; Xu, Gaoshen; Zhan, Zhiwei] Univ South China, Innovat Practice Base Postgrad Training Basic Med, Yueyang 414000, Hunan, Peoples R China.

[Tang, Hailin; Li, Yuxuan; Ye, Dong mei; Zhan, Zhiwei] Univ South China, Hengyang Med Coll, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Yu, Kenan; Yi, Shuijing] Cent South Univ, Xiangya Hosp 3, Dept Gynecol, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Zhan, Zhiwei] H

[Zhan, Zhiwei] Y

[Zhan, Zhiwei] U

[Yi, Shuijing] C

Hengyang Maternal & Child Hlth Hosp, Dept Crit Care Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

SLC7A11;cervical cancer;circEPSTI1;circular RNAs;miR-375

期刊：

AGING-US

ISSN：

1945-4589

年：

2021

卷：

期：

页码：

4663-4673

DOI：

10.18632/aging.202518

基金类别：

This study was supported by funds from the Hunan Provincial Groundbreaking Platform Open Fund of University of China (NO. 18K076), Hunan Provincial Health Commission Project (No. 20201042) and Hunan Science and Technology Innovation Project (NO.2018SK51601), Hunan Provincial Key Subject Fund of Basic Medical Sciences, University of South China and Horizontal Cooperation Project of Yueyang Maternal and Child Health Hospital (NO. 2019KHX43), Hunan Provincial Health Department Project (No. B2019119).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Background: Circular RNAs (circRNAs) is one kind of non-coding RNAs (ncRNAs) and exert crucial functions in biological processes and intracellular gene expression modulation. However, the biological roles and expression status of the majority of circRNAs still remain unknown in cervical cancer. Results: In this study, circEPSTI1 (hsa_circRNA_000479) was significantly upregulated in cervical cancer. We first discovered the impact of circRNA on cell ferroptosis in cervical cancer. Interestingly, circEPSTI1 attenuates the effect of ferritin which ...

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Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis

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