期刊论文

Li-Chen Gao

英文

Drugs in R&D

1174-5886

2022

22

4

311-320

10.1007/s40268-022-00406-2

Science and Technology Key Program of Hunan Province [2016SK2066]; Hunan Province Chinese Medicine Research Program [201940]; Science and Technology Key Program of Hunan Provincial Health Committee [20201904]; Natural Science Foundation of Hunan Province [2021JJ30753]; Hunan Province Foundation of High-level Health Talent (225 Program); Changsha Central Hospital Affiliated to University of South China Foundation of key Program [YNKY202205]

本校为第一机构

BACKGROUND: Cloperastine is a pivotal antibechic widely prescribed to treat cough caused by respiratory diseases. The present trial evaluated the pharmacokinetics (PK), bioequivalence (BE) and safety effects of the generic test (T) tablet of cloperastine after single-dose administration of cloperastine, compared with the original reference (R) tablet of cloperastine. OBJECTIVE: The purpose of this trial was to compare the PK, BE and safety of a test 10 mg versus the reference 10 mg formulation of cloperastine under fasting and postprandial cond...