Association of Single-Nucleotide Polymorphisms in the VDR Gene with Tuberculosis and Infection of Beijing Genotype Mycobacterium tuberculosis

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成果类型：

期刊论文

作者：

Yu, Jinjie;Liu, Mengwen;Mijiti, Xiaokaiti;Liu, Haican;Wang, Quan;...

通讯作者：

Yuan, XQ;Li, GL

作者机构：

[Yuan, Xiuqin; Yu, Jinjie; Yuan, XQ] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Deng, Lele; Zhao, Xiuqin; Liu, Haican; Li, Guilian; Yu, Jinjie; Wan, Kanglin] Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

[Xiao, Hui; Yin, Chunjie; Liu, Mengwen; Li, Machao] Xinjiang Med Univ, Sch Publ Hlth, Urumqi 830011, Xinjiang, Peoples R China.

[Xu, Miao; Mijiti, Xiaokaiti; Wang, Quan] Xinjiang Med Univ, Affiliated Hosp 8, Urumqi 830049, Xinjiang, Peoples R China.

[Anwaierjiang, Aiketaguli] Coll Xinjiang Uyghur Med, Hetian 848000, Peoples R China.

通讯机构：

[Li, GL ] N

[Yuan, XQ ] U

Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

语种：

英文

关键词：

vitamin D receptor;VDR;polymorphism;tuberculosis;Mycobacterium tuberculosis;Beijing lineage

期刊：

INFECTION AND DRUG RESISTANCE

ISSN：

1178-6973

年：

2023

卷：

期：

Volume 16, 2023 - Issue

页码：

3157-3169

DOI：

10.2147/IDR.S407595

基金类别：

This study was supported by the project (2017A03006) of the Major science and technology programs of Xinjiang Uygur Autonomous Region from department of Science and Technology, Xinjiang Uygur Autonomous Region and Mega Project of Research on the Prevention and Control of HIV/AIDS, Viral Hepatitis Infectious Diseases (2018ZX10103001-003-012) from the Ministry of Science and Technology, China. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: The aim of the present study was to investigate the association between vitamin D receptor (VDR) gene polymorphism and tuberculosis susceptibility, as well as the potential interaction of host genetic factors with the heterogeneity of Mycobacterium tuberculosis in the population from Xinjiang, China. METHODS: From January 2019 to January 2020, we enrolled 221 tuberculosis patients as the case group and 363 staff with no clinical symptoms as the control group from four designated tuberculosis hospitals in southern Xinjiang, China. The polymorphisms of Fok I, Taq I, Apa I, Bsm I, rs3...

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Association of Single-Nucleotide Polymorphisms in the VDR Gene with Tuberculosis and Infection of Beijing Genotype Mycobacterium tuberculosis

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