The Biogenesis and Functions of circRNAs and Their Roles in Breast Cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Liting;Jiang, Baohong;Zhu, Hongbo;Gao, Ting;Zhou, Yu;...

通讯作者：

Xie, Liming;Li, Yuehua

作者机构：

[Gong, Fuqiang; Zhu, Hongbo; Zhou, Yu; Li, Yuehua; Tang, Liting; Gao, Ting; Xie, LM; Li, YH; Xie, Liming] Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang, Peoples R China.

[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang, Peoples R China.

[He, Rongfang] Univ South China, Dept Pathol, Affiliated Hosp 1, Hengyang, Peoples R China.

[Li, Yuehua] Univ South China, Hengyang Med Coll, Key Lab Canc Cellular & Mol Pathol Hunan Prov Can, Canc Res Inst, Hengyang, Peoples R China.

通讯机构：

[Xie, LM; Li, YH; Li, Yuehua] U

Univ South China, Affiliated Hosp 1, Dept Med Oncol, Hengyang, Peoples R China.

Univ South China, Hengyang Med Coll, Key Lab Canc Cellular & Mol Pathol Hunan Prov Can, Canc Res Inst, Hengyang, Peoples R China.

语种：

英文

关键词：

circRNA;breast cancer;Cell Proliferation;Apoptosis;Drug Resistance;prognosis;biomarkers

期刊：

FRONTIERS IN ONCOLOGY

ISSN：

2234-943X

年：

2021

卷：

页码：

605988

DOI：

10.3389/fonc.2021.605988

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81902707]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2018JJ6092, 2019JJ50537]; Health and Family Planning Commission of Hunan Province [B2019120, B2019124, C2019114]; Science and Technology Project of Hengyang [S2018F9031021272]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Recent statistics show that breast cancer is among the most frequent cancers in clinical practice. It is also the second-leading cause of cancer-related deaths among women worldwide. CircRNAs are a new class of endogenous regulatory RNA molecules whose 5’ end and 3’ end are connected together to form a covalently closed single-stranded loop by back-splicing. CircRNAs present the advantages of disease-specific expression and excellent expression stability, and they can modulate gene expression at posttranscriptional and transcriptional levels....

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The Biogenesis and Functions of circRNAs and Their Roles in Breast Cancer

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