High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Lu;Zhang, Ji;Xia, Min;Liu, Chang;Zu, Xuyu;...

通讯作者：

Zhong, J.

作者机构：

[Zhong, Jing; Wang, Lu; Xia, Min; Zu, Xuyu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Zhong, Jing; Xia, Min; Zu, Xuyu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Ji] Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China.

[Liu, Chang] Univ Southern Med, Peoples Hosp Chenzhou 1, Sch Clin Med 1, Dept Endocrinol & Metab, Guangzhou 510515, Guangdong, Peoples R China.

通讯机构：

Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hunan, Hengyang, China

语种：

英文

关键词：

Chemoresistance;High mobility group A1;Malignancies;Mechanisms;Targeting treatment

期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

ISSN：

1449-2288

年：

2022

卷：

期：

页码：

4414-4431

DOI：

10.7150/ijbs.72952

基金类别：

Natural Science Foundation of Hunan Province [2019JJ20014]; National Natural Science Foundation of China [81773294, 82170138]; Program of National Health and Family Planning Commission of Hunan [20201929, B2019005]; Chuanshan Talent Project of the University of South China [CS2018-3-35]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

High mobility group A1 (HMGA1) is a nonhistone chromatin structural protein characterized by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of DNA. A large number of studies have confirmed that HMGA1 regulates genes related to tumours in the reproductive system, digestive system, urinary system and haematopoietic system. HMGA1 is rare in adult cells and increases in highly proliferative cells such as embryos. After being stimulated by external factors, it will produce effects through the Wnt/β-catenin...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问