Identification of Candidate Biomarkers for Early Detection of Human Lung Squamous Cell Cancer by Quantitative Proteomics

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成果类型：

期刊论文

作者：

Zeng, Gu-Qing;Zhang, Pang-Fei;Deng, Xingming;Yu, Feng-Lei;Li, Cui;...

通讯作者：

Xiao, Zhi-Qiang

作者机构：

[Qu, Jia-Quan; Li, Cui; He, Qiu-Yan; Xiao, Zhi-Qiang; Li, Jian-Huang; Chen, Yu; Wan, Xun-Xun; Xu, Yan; Yi, Hong; Li, Mao-Yu; Zuo, Jian-Hong; Li, Xin-Hui; Zeng, Gu-Qing; Hu, Rong; Li, Jiao-Yang; Zhang, Pang-Fei; Ye, Xu] Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China.

[Zeng, Gu-Qing] Univ S China, Sch Med, Dept Gen Surg & Operat Surg, Hengyang 421001, Peoples R China.

[Yu, Feng-Lei] Cent S Univ, Dept Cardiothorac Surg, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

[Deng, Xingming] Emory Univ, Sch Med, Dept Radiat Oncol, Atlanta, GA 30322 USA.

[Deng, Xingming] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.

通讯机构：

[Xiao, Zhi-Qiang] C

Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

Molecular & Cellular Proteomics

ISSN：

1535-9476

年：

2012

卷：

期：

页码：

M111.013946

DOI：

10.1074/mcp.M111.013946

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973290, 81172559, 81172302]; Lotus Scholars Program of Hunan Province, China [2007-362]; Science and Technology Department of Hunan Province, China [2010FJ2009]; Nature Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [11JJ2045]; Hunan Provincial Education Department, ChinaHunan Provincial Education Department [09C837]; Hunan Provincial Health Department, China [B2010-037]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

To discover novel biomarkers for early detection of human lung squamous cell cancer (LSCC) and explore possible mechanisms of LSCC carcinogenesis, iTRAQ-tagging combined with two dimensional liquid chromatography tandem MS analysis was used to identify differentially expressed proteins in human bronchial epithelial carcinogenic process using laser capture microdissection-purified normal bronchial epithelium (NBE), squamous metaplasia (SM), atypical hyperplasia (AH), carcinoma in situ (CIS) and invasive LSCC. As a result, 102 differentially expr...

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Identification of Candidate Biomarkers for Early Detection of Human Lung Squamous Cell Cancer by Quantitative Proteomics

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