Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cai, Zhaoxian;Wu, Xiaotian;Song, Zijun;Sun, Shumin;Su, Yunxing;...

通讯作者：

Min, Junxia;Wang, FD

作者机构：

[Min, Junxia; Yu, Yingying; Wang, Fudi; Cheng, Xihao; Su, Yunxing; Wu, Xiaotian; Cai, Zhaoxian; Song, Zijun; Yu, Chao; Min, JX; Sun, Shumin] Zhejiang Univ, Affiliated Hosp 2, Affiliated Hosp 1, Inst Translat Med,Sch Publ Hlth,Canc Ctr,Sch Med, Hangzhou, Zhejiang, Peoples R China.

[Wang, Fudi; Wang, Tianyi; Cai, Zhaoxian] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Hunan, Peoples R China.

[Chen, Wenteng; Yu, Yongping; Chen, En] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China.

[Linkermann, Andreas] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, Div Nephrol, Dresden, Germany.

[Linkermann, Andreas] Albert Einstein Coll Med, Dept Med, Div Nephrol, Bronx, NY USA.

通讯机构：

[Wang, FD ; Min, JX] Z

Zhejiang Univ, Affiliated Hosp 2, Affiliated Hosp 1, Inst Translat Med,Sch Publ Hlth,Canc Ctr,Sch Med, Hangzhou, Zhejiang, Peoples R China.

Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Hunan, Peoples R China.

语种：

英文

期刊：

Cell Discovery

ISSN：

2056-5968

年：

2023

卷：

期：

页码：

104

DOI：

10.1038/s41421-023-00595-3

基金类别：

This study was supported by research grants from the National Natural Science Foundation of China (31930057, 32330047 to F.W.; 31970689 to J.M.; 32100941 to S.S.), and the China Postdoctoral Science Foundation (2020M681898 to S.S.). Work in the Linkermann [31930057, 32330047, 31970689, 32100941]; National Natural Science Foundation of China [2020M681898]; China Postdoctoral Science Foundation [SFB-TRR205, SFB-TRR127, SPP3206]; Medical Clinic 3, University Hospital Carl Gustav Carus Dresden, Germany [(IRTG) 2251]; BMBF; Institute of Translational Medicine of Zhejiang University

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Given the rapidly aging population, aging-related diseases are becoming an excessive burden on the global healthcare system. Metformin has been shown to be beneficial to many age-related disorders, as well as increase lifespan in preclinical animal models. During the aging process, kidney function progressively declines. Currently, whether and how metformin protects the kidney remains unclear. In this study, among longevity drugs, including metformin, nicotinamide, resveratrol, rapamycin, and senolytics, we unexpectedly found that metformin, even at low doses, exacerbated experimentally-induce...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问