Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, Xuefeng;Zu, Xuyu;Tang, Jing;Xiong, Wei;Zhang, Yuan;...

通讯作者：

Jiang, Yuyang

作者机构：

[Tang, Jing; Zhang, Yuan; Yang, Xuefeng; Xiong, Wei] Univ S China, Nanhuan Hosp, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Yuyang; Liu, Feng; Zu, Xuyu] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China.

[Zu, Xuyu] Univ S China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Yuyang] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China.

通讯机构：

[Jiang, Yuyang] T

Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China.

语种：

英文

关键词：

Zbtb7;CDK2;E2F4;cell cycle regulation;promoter activity

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2012

卷：

期：

页码：

1475-1480

DOI：

10.3892/mmr.2012.846

基金类别：

Ministry of Science and Technology, ChinaMinistry of Science and Technology, China [2007AA02Z160]; China Postdoctoral FoundationChina Postdoctoral Science Foundation [200880440390]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Zbtb7, a member of the POK protein family, is involved in tumorigenesis and cellular differentiation by acting as a crucial transcription factor, but its role in cell cycle modulation remains uncharacterized. In the present study, CDK2 and E2F4, two cell cycle regulators, are shown to be downregulated at the mRNA and protein levels by Zbtb7 in HepG2 and QGY7703 cells. Moreover, we demonstrate that the activities of CDK2 and E2F4 promoters were suppressed by the modulation of Zbtb7 levels and that Zbtb7 represses promoter activities through a mechanism involving direct binding of Zbtb7 to the p...

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Zbtb7 suppresses the expression of CDK2 and E2F4 in liver cancer cells: Implications for the role of Zbtb7 in cell cycle regulation

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