Design, synthesis, and antitumor evaluation of trimethoxyflavonoid with arylurea structure against hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Sun, Xueyan;Zhao, Yin;Zhao, Jingduo;Xie, Zhizhong;Lei, Xiaoyong;...

通讯作者：

Tang, G.;Wang, Z.

作者机构：

[Xie, Zhizhong; Zhao, Yin; Lei, Xiaoyong; Sun, Xueyan; Zhao, Jingduo; Tang, Guotao] Heng Yang Med Sch, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang, Hunan, Peoples R China.

[Li, Yong; Liu, Xingyun] Univ South China, Nanhua Hosp, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Huang, Sheng] Jiuzhitang Co Ltd, Changsha, Hunan, Peoples R China.

[Wang, Zhe] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm, Hengyang, Hunan, Peoples R China.

[Wang, Zhe] Univ South China, Affiliated Hosp 2, Dept Pharm, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhe Wang] T

[Guotao Tang] I

The Second Affiliated Hospital, Department of Pharmacy, Hengyang Medical School, University of South China, Hunan, Hengyang, China<&wdkj&>Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, HengYang Medicial School, Hengyang, Hunan, China

语种：

英文

关键词：

antitumor;arylurea flavonoid;glycolysis;trimethoxy;tumor vasculature

期刊：

Drug Development Research

ISSN：

0272-4391

年：

2023

卷：

期：

页码：

406-422

DOI：

10.1002/ddr.22035

基金类别：

This work was financially supported by Hunan Provincial Key Laboratory of tumor microenvironment responsive drug research (Approval number: 2019‐56), the Natural Science Foundation of Hunan Province (Award Number: 2020JJ4534), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, and Tumor Microenvironment Responsive to Natural Product R&D Graduate Innovation Base.

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院系归属：

药学与生物科学学院

摘要：

Simultaneous targeting of tumor vasculature and inhibitors of tumor cell glycolysis may be a promising antitumor strategy. Here, we reported the total synthesis and biological evaluation of A-ring arylurea flavonoid derivatives with B-ring trimethoxy group, which exhibited potent antitumor activity against a variety of tumor cells in vitro. Most of the derivatives showed in vitro antitumor activity on HepG-2, HGC-27, MDA-MB-231, and A549 cells. Among them, compounds 8e, 8f, 8g, 8h, 8j, and 8l also exhibited significant anti-proliferation effect...

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Design, synthesis, and antitumor evaluation of trimethoxyflavonoid with arylurea structure against hepatocellular carcinoma

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