Sigma non-opioid intracellular receptor 1 activation relieves post-stroke cognitive impairment via suppressing AIM2-driven inflammatory response

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成果类型：

期刊论文

作者：

Ma, Hui;Chen, Yue;Zhang, Yi-Mo;Zhang, Yue;Hou, Xiao-Juan;...

通讯作者：

Qiao, Xin;Li, YF

作者机构：

[Ma, Hui; Qiao, Xin; Yang, Yi-Xin; Li, Yun-Feng; Long, Qian] Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China.

[Chen, Yue] Univ South China, Grad Collaborat Training Base Acad Mil Med Sci, Hengyang Med Sch, Hengyang, Peoples R China.

[Zhang, Yi-Mo] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Neurol, Beijing, Peoples R China.

[Zhang, Yue] Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing, Peoples R China.

[Hou, Xiao-Juan] Hebei North Univ, Dept Postgrad, Zhangjiakou, Peoples R China.

通讯机构：

[Li, YF ; Qiao, X] B

Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China.

语种：

英文

关键词：

AIM2;cognitive impairment;hypidone hydrochloride (YL-0919);inflammatory response;ischaemic stroke;sigma non-opioid intracellular receptor 1

期刊：

BRITISH JOURNAL OF PHARMACOLOGY

ISSN：

0007-1188

年：

2025

DOI：

10.1111/bph.70134

基金类别：

National Natural Science Foundation of China; Beijing Natural Science Foundation [7232348, 2021ZD0200900]; [82204360]

机构署名：

本校为其他机构

摘要：

BACKGROUND AND PURPOSE: Ischaemic stroke is one of the most critical causes of death and disability worldwide, but its pharmacotherapies are currently lacking. This study aimed to investigate the effects of the sigma non-opioid intracellular receptor 1 agonist hypidone hydrochloride (YL-0919) on ischaemic stroke as well as the underlying mechanisms. EXPERIMENTAL APPROACH: Male mice were subjected to a middle cerebral artery occlusion (MCAO)/reperfusion (R) model to mimic ischaemic stroke injury. Neurological and cognitive functions were evaluat...

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Sigma non-opioid intracellular receptor 1 activation relieves post-stroke cognitive impairment via suppressing AIM2-driven inflammatory response

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