MiR-29a mediates the apoptotic effects of TNF-α on endothelial cells through inhibiting PI3K/AKT/BCL-2 axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Yunchang;Wen, Hongbo;Leng, Chaoqun;Feng, Shaolong

通讯作者：

Feng, SL

作者机构：

[Cao, Yunchang] Guilin Med Univ, Sch Intelligent Med & Biotechnol, Dept Mol Biol, Guilin, Peoples R China.

[Wen, Hongbo; Leng, Chaoqun] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Peoples R China.

[Feng, Shaolong] Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin, Peoples R China.

[Feng, Shaolong; Feng, SL] Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin 541199, Peoples R China.

通讯机构：

[Feng, SL ] G

Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin 541199, Peoples R China.

语种：

英文

关键词：

apoptosis;atherosclerosis (AS);human umbilical vascular endothelial cells (HUVECs);microRNA (miR)-29a;tumor necrosis factor (TNF)-α

期刊：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

ISSN：

1095-6670

年：

2024

卷：

期：

页码：

e23598-

DOI：

10.1002/jbt.23598

基金类别：

Foundation of State Key Laboratory of Organic Geochemistry, GIGCAS; National Natural Science Foundation of China [41877390]; [SKLOG-202213]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

The signal pathway of TNF‐α inducing human umbilical vascular endothelial cells apoptosis. Abstract Endothelial cell apoptosis driven by inflammation (TNF‐α) plays a critical role in the pathogenesis of atherosclerosis, but the exact molecular mechanisms are not clearly elucidated. MicroRNA (miR)‐29 families (a/b/c) take important roles in pathophysiological processes of atherosclerosis, also the underlying mechanisms have not been fully clarified. The aims are to explore whether or not miR‐29 families mediate the apoptotic effects of TNF...

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MiR-29a mediates the apoptotic effects of TNF-α on endothelial cells through inhibiting PI3K/AKT/BCL-2 axis

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