期刊论文

Luo, Guanghua;Liu, JC

英文

PEERJ

2167-8359

2022

10

10.7717/peerj.13069

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61971451, 81671671]; Health and Family Planning Commission Science Foundation Projects of Hunan Province [C20180187, 202218014518]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ2357]; Major Research Topics of the Health Commission of Hunan Province [20201911]; Key Research and Development Projects of Hunan Province [2019SK2131, 2020SK51826]; Scientific research project of Hunan Provincial Health Commission [202218014518, 202109011222]; Nanhua University Graduate Research and Innovation Project [193YXC029]; National Training Program of Innovation and Entrepreneurship for Undergraduates [202110555106]

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Objective: To evaluate the joint effects of cerebral small vessel disease (CSVD)related imaging biomarkers in patients of type 2 diabetes mellitus (T2DM) with cognitive impairment. Methods: This study is a retrospective cohort study. A total of 227 participants (115 patients with T2DM and 112 healthy control subjects) were enrolled in this study. Cognitive function assessments were evaluated using the Mini-Mental State Examination and the Montreal Cognitive Assessment. The burden of CSVD markers, including the lacunes, white matter hyperintensi...