This project was supported by the Scientific and Technological Projects of Hunan Province [No.2019JJ80005, No. 2019JJ40317], the National Natural Science Foundation of China [No. 31872315, No. 31572349], the Scientific Research Fund of Hunan Provincial Education Department [No. 18A028] and the open project by the key laboratory of protein chemistry and development biology of state education ministry of China, Hunan Normal University [No.2015DF07]. We want to thank Professor Hua She, Department of Pharmacology, Emony University School of Medicine, 615 Michael Street, Atlanta GA, 30322, USA., for his technical support and critical manuscript revision.