期刊论文

中文

中国骨质疏松杂志

1006-7108

2012

18

6

583-588

10.3969/j.issn.1006-7108.2012.06.022

本校为第一机构

骨质疏松是一种常见的以骨量减少伴有骨组织微结构的破损所致骨脆性骨折危险性增高的全身性代谢性骨病.随着人口老龄化的加大,骨质疏松(特别是绝经后骨质疏松)的相关治疗和及其对社会经济学的影响,将进一步加大.随着对破骨细胞促进骨吸收和成骨细胞促进骨形成的及其它们之间的分子间信号传递的骨生物学详尽的认识,一些新的治疗方法逐渐得到了人们的认可.新的治疗策略旨在抑制骨的吸收,而增加骨的形成.目前最有前途的新的治疗方法包括:地舒单抗,是一种特异性靶向核因子κB 受体活化因子配体(RANKL) 的单克隆抗体;奥达卡替,一种破骨细胞组织蛋白酶K抑制剂;沙拉替尼,一种Src激酶抑制剂;巴多昔芬,一...

Osteoporosis （OP） is a common bone disease characterized by a systemic impairment of bone mass and microarehitecture which results in fragility fractures. With the increasing aged population, the treatment and socio-economic effect on osteoporosis, especially on postmenopausal osteoporosis, will further increase. A sufficient understanding of bone biology with molecules signaling to the communication between bone-resorbing osteoclasts and bone-forming osteoblasts and the orchestrating signaling network has led to gradually recognized novel th...