Identification of IgH gene rearrangement and immunophenotype in an animal model of Epstein–Barr virus-associated lymphomas

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成果类型：

期刊论文

作者：

Zhang, Yang;Peng, Xueqin;Tang, Yunlian;Gan, Xiaoning;Wang, Chengkun;...

通讯作者：

Wu, Yimou;Gan, Runliang

作者机构：

[Gan, Runliang; Zhang, Yang; Xie, Xiaoli; Tang, Yunlian; Wang, Chengkun; Peng, Xueqin; Gan, Xiaoning] Univ South China, Coll Med, Canc Res Inst, Chang Sheng Xi Ave 28, Hengyang 421001, Hunan, Peoples R China.

[Xie, Lu] Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol SCBIT, Shanghai 201203, Peoples R China.

[Wu, Yimou] Univ South China, Hunan Prov Key Lab Special Pathogen Prevent & Con, Hengyang 421001, Hunan, Peoples R China.

[Gan, Runliang] Univ South China, Chang Sheng Xi Ave 28, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou; Gan, Runliang] U

Univ South China, Hunan Prov Key Lab Special Pathogen Prevent & Con, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Chang Sheng Xi Ave 28, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*EBV-associated lymphoma;*Epstein-Barr virus (EBV);*SCID mouse;*gene rearrangement;*immunophenotype

期刊：

Journal of Medical Virology

ISSN：

0146-6615

年：

2016

卷：

期：

页码：

1804-1813

DOI：

10.1002/jmv.24526

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500169, 81272182]; Foundation of the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2014-405]; Construct Program of the Key Discipline in Hunan Province [2011-76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Epstein–Barr virus (EBV) is a human oncogenic herpesvirus associated with lymphoma and nasopharyngeal carcinoma. Because the susceptible hosts of EB virus are limited to human and cotton-top tamarins (Saguinus oedipus), there have been no appropriate animal models until the lymphoma model induced by EBV in human peripheral blood lymphocyte (hu-PBL)/SCID chimeric mice was reported. However, it is still controversial whether the EBV-associated lymphoma induced in hu-PBL/SCID mice is a monoclonal tumor. In this study, we transplanted normal human...

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Identification of IgH gene rearrangement and immunophenotype in an animal model of Epstein–Barr virus-associated lymphomas

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