Aldo-keto reductase 1B10 as a Carcinogenic but Not a Prognostic Factor in Colorectal Cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ye, Xu;Wang, Tao;Zhong, Liyuan;Farres, Jaume;Xia, Jiliang;...

通讯作者：

Zeng, Xi;Cao, DL

作者机构：

[Ye, Xu] Cent South Univ, Hunan Canc Hosp, Changsha 410031, Hunan, Peoples R China.

[Ye, Xu] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410031, Hunan, Peoples R China.

[Cao, Deliang; Zeng, Xi; Wang, Tao; Zhong, Liyuan; Xia, Jiliang] Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang Med Coll, 28 W Changsheng Rd, Hengyang 421009, Hunan, Peoples R China.

[Farres, Jaume] Univ Autonoma Barcelona, Dept Biochem & Mol Biol, E-08193 Barcelona, Spain.

通讯机构：

[Cao, DL ; Zeng, X] U

Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang Med Coll, 28 W Changsheng Rd, Hengyang 421009, Hunan, Peoples R China.

语种：

英文

关键词：

AKR1B10;Biomarker;Colorectal cancer;Tissue microarrays;and DNA damage

期刊：

JOURNAL OF CANCER

ISSN：

1837-9664

年：

2024

卷：

期：

页码：

1657-1667

DOI：

10.7150/jca.91064

基金类别：

Natural Science Foundation of Hunan province [2021JJ40483, 2021JJ40502]; Key Project of Hunan Department of Public Health [202201043124]; Hunan Changzhutan National Independent Innovation None Special Project [2018XK2106]; PhD Scientific Research Start-up Fund of University of South China [200XQD075]; Spanish Ministerio de Ciencia e Innovacion (Agencia Estatal de Investigacion); [PID2020-119424RB-I00/AEI/10.13039/501100011033]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Colorectal cancer (CRC) is the leading cause of cancer death, but little is known about its etiopathology. Aldo-keto reductase 1B10 (AKR1B10) protein is primarily expressed in intestinal epithelial cells, but lost in colorectal cancer tissues. This study revealed that AKR1B10 may not be a prognostic but an etiological factor in colorectal tumorigenesis. Using a tissue microarray, we investigated the expression of AKR1B10 in tumor tissues of 592 colorectal cancer patients with a mean follow-up of 25 years. Results exhibited that AKR1B10 protein was undetectable in 374 (63.13%), weakly positive ...

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Aldo-keto reductase 1B10 as a Carcinogenic but Not a Prognostic Factor in Colorectal Cancer

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