Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant that stimulates the migration of monocytes and plays an important role in the development, progression, and destabilization of atherosclerosis (AS). And MCP-1 can be a novel therapeutic target against AS. In this study, we devised a novel strategy for anti-MCP-1 therapy by transfecting MCP-1 siRNA expression vectors into the in vitro cultured human umbilical vein endothelial cells (HUVECs). siRNA expression vectors (named S1, S2, and S3) were constructed and transfected into HUVECs. The results indicated that three MCP-1 si...
