Conceptualization, Z.X., M.D. and J.L.; methodology, Z.X., M.D. and J.L.; software, Z.X.; validation, Z.X., M.D. and J.L.; formal analysis, M.D., X.G. and Z.C.; investigation, E.S. and J.Z.; resources, X.G.; data curation, Z.C.; writing—original draft preparation, Z.X. and J.L.; writing—review and editing, Z.X. and M.D.; visualization, Z.X.; supervision, J.Z., X.G. and Z.C.; project administration, X.G. and Z.C.; funding acquisition, X.G. and Z.C. All authors have read and agreed to the published version of the manuscript. This work was supported by the National Key R&D Program of China (2019YFE0110400), National Natural Science Foundation of China (81971621, 82102087, 82102054), Key R&D Program of Hunan Province (2021SK2035), Natural Science Foundation of Hunan (2022JJ30039, 2022JJ40392), and Clinical Research 4310 Program of the First Affiliated Hospital of The University of South China (4310-2021-K06).