Peptidic Monodisperse PEG \"Comb\" as Multifunctional \"Add-On\" Module for Imaging-Traceable and Thermo-Responsive Theranostics. - 成果

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Peptidic Monodisperse PEG "Comb" as Multifunctional "Add-On" Module for Imaging-Traceable and Thermo-Responsive Theranostics.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhu, Junfei;Zhang, Huaibin;Chen, Kexin;Li, Yu;Yang, Zhigang;...

通讯作者：

Jiang, Zhong-Xing

作者机构：

[Jiang, Zhong-Xing; Zhu, Junfei; Zhang, Huaibin; Yang, Zhigang] Wuhan Univ, Sch Pharmaceut Sci, Res Ctr Fluorinated Pharmaceut, Hubei Prov Engn & Technol, Wuhan 430071, Hubei, Peoples R China.

[Li, Yu; Zhou, Xin; Chen, Shizhen; Zhang, Huaibin] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan 430071, Hubei, Peoples R China.

[Chen, Kexin; Zheng, Xing] Univ South China, Grp Lead Compound, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

通讯机构：

[Jiang, Zhong-Xing] W

Wuhan Univ, Sch Pharmaceut Sci, Res Ctr Fluorinated Pharmaceut, Hubei Prov Engn & Technol, Wuhan 430071, Hubei, Peoples R China.

语种：

英文

关键词：

drug delivery;imaging;liposome;polyethylene glycols;stimuli-responsive biomaterials

期刊：

Advanced Healthcare Materials

ISSN：

2192-2640

年：

2020

卷：

期：

页码：

e1901331

DOI：

10.1002/adhm.201901331

基金类别：

The authors are thankful for the financial support from the National Key R&D Program of China (2016YFC1304704, 2018YFA0704000), the National Natural Science Foundation of China (21572168, and 81625011), and the Key Research Program of Frontier Sciences, CAS (QYZDY-SSW-SLH018).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Monodisperse polyethylene glycols–modified (M-PEGylated) biomaterials exhibit high structural accuracy, biocompatibility, and fine-tunable physicochemical properties. To develop “smart” drug delivery systems in a controllable and convenient manner, a peptidic M-PEG “comb” with fluorinated L-lysine side chains and a fluorescent N-terminal is conveniently prepared as a 19F magnetic resonance imaging (19F MRI) and fluorescence dual-imaging traceable and thermo-responsive “add-on” module for liposomal theranostics in cancer therapy. The pept...

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Peptidic Monodisperse PEG "Comb" as Multifunctional "Add-On" Module for Imaging-Traceable and Thermo-Responsive Theranostics.

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