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Peptidic Monodisperse PEG "combs" with Fine-Tunable LCST and Multiple Imaging Modalities

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成果类型:
期刊论文
作者:
Zhu, Junfei;Xiao, Yan;Zhang, Huaibin;Li, Yu;Yuan, Yaping;Yang, Zhigang;Chen, Shizhen;Zheng, Xing;Zhou, Xin;Jiang, Zhong-Xing*
通讯作者:
Jiang, Zhong-Xing
作者机构:
[Li, Yu; Jiang, Zhong-Xing; Zhu, Junfei; Zhang, Huaibin; Yang, Zhigang] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China.
[Xiao, Yan; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
[Zhou, Xin; Chen, Shizhen; Yuan, Yaping] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan 430071, Peoples R China.
通讯机构:
[Jiang, Zhong-Xing] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China.
语种:
英文
期刊:
Biomacromolecules
ISSN:
1525-7797
年:
2019
卷:
20
期:
3
页码:
1281-1287
基金类别:
National Key R&D Program of China [2016YFC1304704]; National Natural Science Foundation of China [21572168, 81625011]; Key Research Program of Frontier Sciences, CAS [QYZDY-SSW-SLH018]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Thermosensitive and imaging-traceable materials with fine-tunable lower critical solution temperature (LCST) around body temperature are highly valuable in biomedicine. However, such materials are rare because it is challenging to fine-tune the LCST and incorporate suitable imaging modalities. Herein, peptidic monodisperse polyethylene glycol (M-PEG) "combs" with fine-tunable LCST, "hot spot" fluorine-19 magnetic resonance imaging ((19)F MRI), thermoresponsive fluorescent imaging, and drug loading ability were developed through accurately programming their structures during solid phase peptide synthesis (SPPS). The easy availability, structural accuracy, biocompatibility, and versatility provide the M-PEG "combs" with promising prospects as thermoresponsive and imaging-traceable biomaterials for controlled drug delivery.

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