The size and depth of the focused ultrasound beam mainly depend on the geometrical size and acoustic parameters of the HIFU transducer. Among a number of concave self-focusing transducer (e.g. Sonablate-500, Focus Surgery, USA; FEPBY02, Beijing Yuande Biomedical Engineering, China; Model-JC, Chongqing HAIFU™, China; etc.) applied in practice, The −6 dB beam size of HIFU system in its focal region is usually 1–3 mm in width and about 10 mm in length. However, the detectable and treatable