期刊论文

Tan, Xiang-Wen;Yu, Cui-Yun

英文

Drug Delivery

1071-7544

2017

24

1

459-466

10.1080/10717544.2016.1264499

We deeply acknowledge the financial support provided by National Natural Science Foundation of China (81471777, 81102409), and the project (2014GK3082) was supported by a research grant from the Department of Science and Technology of Hunan Province. Support from the scientific research project of traditional Chinese Medicine in Hunan Province (201412), and financial supports from the Young Talent Program of the University of South China to Cui-Yun Yu, the Health Department of Hunan Province 225 Talent Project and the Construct Program of the Key Discipline in Hunan Province are gratefully acknowledged.

本校为第一且通讯机构

A novel type of macromolecular prodrug delivery system is reported in this research. The N-galactosylated-chitosan-5-fluorouracil acetic acid conjugate (GC-FUA) based nanoparticle delivery system was evaluated in vitro and in vivo. Biocompatibility of GC-FUA-NPs was screened by BSA adsorption test and hemolysis activity examination in vitro. Cytotoxicity and cellular uptake study in HepG2 and A549 cells demonstrated that compared to free 5-Fu, the GC-FUA-NPs play great function in killing cancer cells for the cell endocytosis mediated by asialo...