National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102409]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [10C1179]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [13JJ6096]; Research Grant of Department of Science and Technology of Hunan Province [2012TT2030]; Construct Program of the Key Discipline in Hunan Province
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
The fabrication and evaluation of a natural pectin-based drug delivery system are reported in this study. The drug delivery system displays specific active targeting ability to hepatocellular carcinoma due to the presence of excess galactose residues in the polymer structure as the natural targeting ligands. The system was prepared under very mild conditions in an aqueous medium containing Ca2+ and CO3 2- ions, generating uniform pectin-based nanoparticles with an average diameter of 300 nm, and the drug-loading content of anticancer drug 5-flu...
