Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway

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成果类型：

期刊论文

作者：

Cao, Yanqun;Chen, Hao;Tan, Yinna;Yu, Xu-Dong;Xiao, Chuli;...

通讯作者：

He, Zhiming;Shu, XH

作者机构：

[Shu, Xinhua; Xiao, Chuli; He, Zhiming; Yu, Xu-Dong; Cao, Yanqun; Chen, Hao; Li, Yin] Shaoyang Univ, Pu Ai Med Sch, Brain Cognit & Brain Dis Branch, Shaoyang 422000, Peoples R China.

[Tan, Yinna] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Anesthesiol Dept, Hengyang 421000, Peoples R China.

[Shu, Xinhua; Reilly, James] Glasgow Caledonian Univ, Dept Biol & Biomed Sci, Glasgow G4 0BA, Scotland.

[Shu, Xinhua] Glasgow Caledonian Univ, Dept Vis Sci, Glasgow G4 0BA, Scotland.

通讯机构：

[Shu, XH ; He, ZM] S

Shaoyang Univ, Pu Ai Med Sch, Brain Cognit & Brain Dis Branch, Shaoyang 422000, Peoples R China.

Glasgow Caledonian Univ, Dept Biol & Biomed Sci, Glasgow G4 0BA, Scotland.

Glasgow Caledonian Univ, Dept Vis Sci, Glasgow G4 0BA, Scotland.

语种：

英文

关键词：

PKA-CREB-BDNF signaling pathway;P–coumaric acid;chronic restraint stress;inflammation;mental disorders;network pharmacology

期刊：

Physiology & Behavior

ISSN：

0031-9384

年：

2024

卷：

273

页码：

114415

DOI：

10.1016/j.physbeh.2023.114415

基金类别：

Lotus Scholarship Program of Hunan Province, China [2019]; Natural Science Foundation of Hunan Province [2022JJ50167, 19A449, 21A0474]; Education Department of Hunan Province [202304117888, S202310547009]; Hunan Provincial Health Commission [S20-02]; National College Students Innovation and Entrepreneurship Training Program [SNRF2021]; TENOVUS Scotland; Chief Scientist Office/the RS Macdonald Charitable Trust; [2023JJ50274]; [2022JJ50220]

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摘要：

There is a body of evidence to suggest that chronic stress modulates neurochemical homeostasis, alters neuronal structure, inhibits neurogenesis and contributes to development of mental disorders. Chronic stress-associated mental disorders present common symptoms of cognitive impairment and depression with complex disease mechanisms. P-coumaric acid (p-CA), a natural phenolic compound, is widely distributed in vegetables, cereals and fruits. p-CA exhibits a wide range of health-related effects, including anti-oxidative-stress, anti-mutagenesis, anti-inflammation and anti-cancer activities. The...

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Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway

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