期刊论文

Wu, YM

英文

Human Vaccines & Immunotherapeutics

2164-5515

2023

19

2

2234790

10.1080/21645515.2023.2234790

We would like to give our sincere appreciation to the helps of the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No. 2014-5, and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351). This work was supported by the Hunan clinical medical technology innovation guidance project [Grant numbers 2021SK50402], [82101869], National Natural Science Foundation of China [Grant numbers 81702046 and 82002182], Natural Science Foundation of Hunan Province [Grant numbers 2021JJ40479 and 2019JJ50535], Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [grant number 2015–351], HunanProvincial Key Laboratory for Special Pathogens Prevention and Control Foundation [grant number 2014–5]. We would like to give our sincere appreciation to the helps of the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No. 2014-5, and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351).

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Syphilis, a chronic systemic sexually transmitted disease, is caused by the bacterium Treponema pallidum (T. pallidum). Currently, syphilis remains a widespread infectious disease with significant disease burden in many countries. Despite the absence of identified penicillin-resistant strains, challenges in syphilis treatment persist due to penicillin allergies, supply issues, and the emergence of macrolide-resistant strains. Vaccines represent the most cost-effective strategy to prevent and control the syphilis epidemic. In light of the ongoin...