期刊论文

中文

中国现代医学杂志

1005-8982

2009

19

9

1346-1348

10.3969/j.issn.1005-8982.2009.09.018

本校为第一机构

目的 探讨骨质疏松小鼠模型中骨组织Caveolin-1表达变化.方法 双侧卵巢切除法建立小鼠骨质疏松模型;用双能X线骨密度仪测骨矿密度;HE染色观察骨组织变化;免疫组织化学法检测骨组织Cave-olin-1表达.结果 去卵巢12周小鼠股骨骨矿密度明显下降,同时其HE染色组织学改变符合骨质疏松症病理变化.骨质疏松组小鼠骨组织Caveolin-1表达明显低于对照组,Caveolin-1在小鼠幼年组表达最高.结论 去卵巢骨质疏松模型小鼠骨组织Caveolin-1表达降低,Caveolin-1信号分子可能具有抑制骨质疏松形成与发展作用.

[Objective] To investigate bone caveolin-1 expression in osteoporosis mice. [Methods] The osteoporosis model was established by ovariectomy of mice. The bone mineral density （BMD） was measured by dual-energy X-ray absorptimetry. The bone history was observed by HE staining. The caveolin-1 expression was determined by immunohistochemistry. [Results] The bone mineral density of mouse was decreased significantly in ovariectomy group after 12 weeks. Meanwhile, the bone histology showed pathological changes in osteoporosis mice. The cave- ohn-1 ex...