[ Objective]The aim of this study was to explore the malignant transformation effect on cytotoxic of human bronchial epithelial cell (BEAS-2B) induced by uranium mine dust, further investigate the cause and mechanism of human lung cancer. [Methods] The immortalized human bronchial epithelial ceils BEAS-2B were treated with uranium mine dust at the concentrations of different dose,including a negative control group and the group protected by DMSO. The characteristics of the cellular biology and the malignant transformation phenotype of cells w...