期刊论文

中文

中国现代医学杂志

1005-8982

2003

13

17

20-21,25

10.3969/j.issn.1005-8982.2003.17.008

湖南省卫生厅科研项目基金资助 （编号 :995 1）；

本校为第一机构

目的:了解摩托车使用无铅汽油后其尾气的毒性作用.方法:选用40只健康昆明种成年小鼠,体重24.6～36.3g,平均体重为(30.50±5.12)g,随机分为4组,染毒组分将摩托车尾气吸收液按1∶2,1∶4,1∶16进行稀释后进行灌胃染毒,溶剂对照组用二甲基亚砜(DMSO)按1∶2用蒸馏水稀释后进行灌胃,每天1次,每周5d,共计40d.测定小鼠体内谷胱甘肽(GSH)含量、谷胱甘肽过氧化物酶(GSH-Px)活性以及骨髓微核、精子畸形率的变化.结果:摩托车尾气染毒各组可致全血及肝组织匀浆中GSH含量及GSH-Px活性降低,高浓度时表现更为明显,与对照组比较差异有显著性(P＜0.05);骨髓嗜多染红细胞微核及精子畸变率增高,存在剂量-效应关系,高...

Objective:To research the toxicity of motorbike exhaust using lead-free gasoline.Methods:40 mice were distributed in four groups randomly and administrated by gavage with the absor bent solution motorbike exhaust deluted by distilled water in 1∶2, 1∶4,1∶16, and DMSO deluted by distilled water in 1∶2 only one time every day for 40 days. The changes of the content of glutathione (GSH) and the activity of glutathione peroxidase (GSH-Px)in blood and liver cytoplasm and the effects of the marrow micronucleus and semina deformity rate in mice wer...