The protective effects of gypenosido (GPS) on endotoxic ( ET) damage of the iaolated papillafy muscles in guinea pigs were reported in this paper.ET produced quick positive inotropism at first and then continuous negative inotropism was observed. ET also inhibited the activity of supemxide dismutase (SOD) , increased the ontent of malondialdehyde ( MDA) , and shortened the functional refractory period ( FRP) , elevated the excitability and increased the automaticity induced by adrenaline. In papillary muscles, GPS inhibited the negative in- otmpism, and attenuated the chango in FRP, automatici...
