NGL-2 is a new partner of PAR complex in axon differentiation

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xu, Gang;Wang, Rong;Wang, Zeyou;Lei, Qianqian;Yu, Zhibin;...

通讯作者：

Wu, Minghua

作者机构：

[Xu, Gang] Cent S Univ, Hunan Prov Tumor Hosp, Changsha 410078, Hunan, Peoples R China.

[Xu, Gang] Cent S Univ, Affiliated Tumor Hosp, Xiangya Med Sch, Changsha 410078, Hunan, Peoples R China.

[Wu, Minghua; Wang, Zeyou; Lei, Qianqian; Yu, Zhibin; Wang, Rong; Li, Peiyao; Liu, Changhong; Li, Guiyuan; Xu, Gang] Cent S Univ, Canc Res Inst, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China.

[Xu, Gang] Univ South China, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Yang, Zengjie] Fox Chase Canc Ctr, Canc Biol Program, Philadelphia, PA 19111 USA.

通讯机构：

[Wu, Minghua] C

Cent S Univ, Canc Res Inst, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

LRRC4;NGL-2;axon differentiation;microtubule stability;neuronal polarity

期刊：

Journal of Neuroscience

ISSN：

0270-6474

年：

2015

卷：

期：

页码：

7153-7164

DOI：

10.1523/JNEUROSCI.4726-14.2015

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31201023]; Open-End Fund for the Valuable and Precision Instruments of Central South University [CSUZC2014041]; 111 ProjectMinistry of Education, China - 111 Project [111-2-12]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Neuronal polarization is pivotal for neural network formation during brain development. Axon differentiation is a hallmark of initial neuronal polarization. Here, we report that the leucine-rich repeat-containing protein netrin-G ligand-2 (NGL-2) as a polarity regulator that localizes asymmetrically in rat hippocampal neurons and is required for differentiation of the future axon. NGL-2 was associated with PAR complex, and this interaction resulted in local stabilization of axonal microtubules. Further study showed that the C terminal of NGL-2 ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

NGL-2 is a new partner of PAR complex in axon differentiation

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问