FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARγ-LXRα pathway in THP1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Lin, Xiao-Long;He, Xing-Lan;Zeng, Jun-Fa;Zhang, Hai;Zhao, Yue;...

通讯作者：

Wang, Zuo

作者机构：

[Lin, Xiao-Long; He, Xing-Lan; Zhang, Hai; Wang, Zuo] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China.

[Lin, Xiao-Long] Third Peoples Hosp Huizhou, Dept Pathol, Huizhou, Guangdong, Peoples R China.

[Zeng, Jun-Fa] Univ South China, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

[Zhao, Yue; Tan, Jian-Kai] Univ South China, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Zuo] U

Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Cell types

期刊：

DNA AND CELL BIOLOGY

ISSN：

1044-5498

年：

2014

卷：

期：

页码：

514-521

DOI：

10.1089/dna.2013.2290

基金类别：

Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Visiting Scholar Foundation of Key Laboratory for Biorheological Science and Technology (Chongqing University) of Ministry of Education; construct program of the key discipline in Hunan province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

FGF21, a member of the fibroblast growth factor superfamily, is an important endogenous regulator of systemic glucose and lipid metabolism. Elevated serum FGF21 levels have been reported in subjects with coronary heart disease and carotid artery plaques. However, whether FGF21 is associated with atherosclerotic diseases remains unclear. In this study, the effects of FGF21 on cholesterol efflux in THP1 macrophage-derived foam cells and the underlying mechanisms were investigated. THP1 macrophage-derived foam cells were incubated with 0, 25, 50, ...

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FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARγ-LXRα pathway in THP1 macrophage-derived foam cells

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