The C-terminus of the tail fiber protein of PB1-like phages is responsible for the host recognition

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成果类型：

期刊论文

作者：

Wu, Zhiying;Huang, Haixia;Peng, Shihui;Tam, Heng-Keat;Liu, Ying;...

通讯作者：

Bai, QQ

作者机构：

[Liu, Ying; Bai, Qinqin; Peng, Shihui; Huang, Haixia; Wu, Zhiying; Chen, Lili] Univ South China, Hengyang Med Sch, Sch Publ Hlth, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.

[Wu, Zhiying] Shanghai Pudong New Area Hlth Supervis Inst, Shanghai Pudong New Area Ctr Dis Control & Preven, Shanghai 200136, Peoples R China.

[Tam, Heng-Keat] Univ South China, Hengyang Med Sch, Dept Med Microbiol, Hengyang 421001, Hunan, Peoples R China.

[Tam, Heng-Keat] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Tam, Heng-Keat] Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss Key Lab Birth Defect Res & Prev, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Bai, QQ ] U

Univ South China, Hengyang Med Sch, Sch Publ Hlth, Dept Publ Hlth Lab Sci, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

PB1-like phages;Tail fiber proteins;C-terminus;Host absorption;Pseudomonas aeruginosa

期刊：

Virus Genes

ISSN：

0920-8569

年：

2025

卷：

期：

页码：

640-643

DOI：

10.1007/s11262-025-02175-x

基金类别：

This research was supported by the Natural Science Foundation of Hunan Province (No. 2023JJ30501) and the Scientific Research Fund of Hunan Provincial Education Department (No. 21B0399).

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

公共卫生学院

摘要：

PB1-like phages belong to Pbunavirus and are widespread in various environments. This group of phages is a promising candidate for treating human or animal infectious diseases caused by antibiotic-resistant P. aeruginosa. The lipopolysaccharide (LPS) has been identified as the receptor of different PB1-like phages, while little is known about the receptor-binding proteins (RBPs) of these phages. We constructed the tail fiber protein (gp50) of a PB1-like phage, PHW2, and its C- or N-terminus truncation variants to identify its role during the phage infection. The anti-gp50((453-964)) antibody s...

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The C-terminus of the tail fiber protein of PB1-like phages is responsible for the host recognition

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