The role of histone modifications in pulmonary hypertension: From mechanisms to therapeutic targets

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成果类型：

期刊论文

作者：

Yang, Yunhua;Gong, Shaoxin;Liang, Na;Li, Zhouxin;Duan, Xiaoyu;...

通讯作者：

Wang, AP;Lei, XY

作者机构：

[Li, Zhouxin; Duan, Xiaoyu; Wang, Aiping; Yang, Yunhua; Xie, Tong] Univ South China, Inst Neurosci Res, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Gong, Shaoxin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

[Duan, Xiaoyu; Liang, Na; Xie, Tong] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Lei, Xiaoyong] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Coll, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

[Lei, Xiaoyong] Xiangnan Univ, Coll Pharm, Chenzhou 423000, Hunan, Peoples R China.

通讯机构：

[Wang, AP ; Lei, XY ] U

Univ South China, Inst Neurosci Res, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang Med Coll, Sch Pharmaceut Sci, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

HDAC1;Histone modifications;Precision medicine;Pulmonary hypertension;SIRT1;p300

期刊：

Vascular Pharmacology

ISSN：

1537-1891

年：

2025

卷：

160

页码：

107519

DOI：

10.1016/j.vph.2025.107519

基金类别：

National Natural Science Foun-dation of China [32471179]; Natural Science Foundation of the Province of Hunan [2025JJ81044]; Key Program of Education Department of Hunan Province [21A0274]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Pulmonary hypertension is a progressive vascular disease characterized by pulmonary vascular remodeling, with high mortality and poor prognosis despite advances in medical therapy. Recently, histone modification therapies for pulmonary hypertension have received more attention. Studies have shown that abnormal histone modifications and the enzymes responsible for these alterations can drive pulmonary vascular cell proliferation, migration, and anti-apoptosis by regulating chromatin structure and gene expression, thereby promoting pulmonary vascular remodeling in pulmonary hypertension. This re...

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The role of histone modifications in pulmonary hypertension: From mechanisms to therapeutic targets

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