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MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.

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成果类型:
期刊论文
作者:
Zhou, Huijun;Gong, Han;Zeng, Xiaohui;Zeng, Chong;Liu, Dian;...
作者机构:
[Zhou, Huijun] Department of Gastroenterology and Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China
[Gong, Han] School of Life Sciences, Hunan Province Key Laboratory of Basic and Applied Hematology, Central South University, Changsha, Hunan 410011, P.R. China
[Zeng, Xiaohui] Department of Oncology, Hunan Institute of Schistosomiasis Control/The Third Hospital of Hunan Province, Yueyang, Hunan 414000, P.R. China
[Zeng, Chong] Department of Respiratory and Critical Care Medicine, The Seventh Affiliated Hospital, Hengyang Medical School, University of South China, Changsha, Hunan 410119, P.R. China
[Liu, Dian] Department of Lymphoma and Abdominal Radiotherapy, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China
语种:
英文
关键词:
PEBP1;PI3K/AKT pathway;esophageal squamous cell carcinoma;m6A modification;methylenetetrahydrofolate dehydrogenase 2
期刊:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN:
1107-3756
年:
2025
卷:
55
期:
5
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
One‑carbon metabolism plays an important role in cancer progression. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme in one‑carbon metabolism, is dysregulated in several cancer types. However, the precise role and mechanisms of MTHFD2 in esophageal squamous cell carcinoma (ESCC) remain unclear. The present study unravels the multifaceted mechanisms by which MTHFD2 contributes to ESCC pathogenesis. Bioinformatics analyses revealed significant upregulation of MTHFD2 in ESCC tumor tissues, which was associated with adv...

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