MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification-mediated upregulation and modulation of the PEBP1-RAF1 interaction

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Huijun;Gong, Han;Zeng, Xiaohui;Zeng, Chong;Liu, Dian;...

通讯作者：

Zhang, YY

作者机构：

[Zhou, Huijun] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Dept Gastroenterol & Urol,Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.

[Zeng, Xiaohui; Zhou, Huijun] Third Hosp Hunan Prov, Hunan Inst Schistosomiasis Control, Dept Oncol, Yueyang 414000, Hunan, Peoples R China.

[Gong, Han] Cent South Univ, Sch Life Sci, Hunan Prov Key Lab Basic & Appl Hematol, Changsha 410011, Hunan, Peoples R China.

[Zeng, Chong] Univ South China, Affiliated Hosp 7, Hengyang Med Sch, Dept Resp & Crit Care Med, Changsha 410119, Hunan, Peoples R China.

[Liu, Dian] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Dept Lymphoma & Abdominal Radiotherapy,Hunan Canc, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Zhang, YY ] C

Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

PEBP1;PI3K/AKT pathway;esophageal squamous cell carcinoma;m6A modification;methylenetetrahydrofolate dehydrogenase 2

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2025

卷：

期：

页码：

1-15

DOI：

10.3892/ijmm.2025.5509

基金类别：

Hunan Provincial Health High Level Talent Support Program

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

One‑carbon metabolism plays an important role in cancer progression. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme in one‑carbon metabolism, is dysregulated in several cancer types. However, the precise role and mechanisms of MTHFD2 in esophageal squamous cell carcinoma (ESCC) remain unclear. The present study unravels the multifaceted mechanisms by which MTHFD2 contributes to ESCC pathogenesis. Bioinformatics analyses revealed significant upregulation of MTHFD2 in ESCC tumor tissues, which was associated with adv...

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MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification-mediated upregulation and modulation of the PEBP1-RAF1 interaction

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