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The Updated Concept of Genome and Its Implications in Biotechnological Research and Molecular Diagnostics

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成果类型:
期刊论文
作者:
Xiao, Li;Saldivar, Juan-Sebastian;Zhou, Cuilan;Chen, Chengli;Zhang, Jia;Sirois, Pierre;Li, Kai*
通讯作者:
Li, Kai
作者机构:
[Li, Kai; Xiao, Li] Suzhou Univ, Affiliated Hosp 2, Mol Med Ctr, Suzhou 215004, Jiangsu, Peoples R China.
[Li, Kai; Chen, Chengli; Xiao, Li] Biotecan Ctr Mol Med, Shanghai, Peoples R China.
[Zhou, Cuilan; Xiao, Li] Nanhua Univ, SNP Inst, Hengyang, Hunan, Peoples R China.
[Saldivar, Juan-Sebastian] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA.
[Zhang, Jia] Novartis Res Fdn, Genom Inst, San Diego, CA USA.
通讯机构:
[Li, Kai] Suzhou Univ, Affiliated Hosp 2, Mol Med Ctr, Suzhou 215004, Jiangsu, Peoples R China.
语种:
英文
关键词:
Genome;Human genome;Reference genome;Molecular diagnostics
期刊:
Molecular Biotechnology
ISSN:
1073-6085
年:
2009
卷:
41
期:
2
页码:
152-156
基金类别:
Hunan Provincial [04A048]; Chinese Education Ministry [205106]; Chinese National 863 Major [2007AA02Z4A7]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
We propose a short definition of GENOME: The full complement of genetic materials possessed by an intracellular parasite, a cell, or an organism. Accordingly, the human genome is the entire complement of inherited genetic materials possessed by an individual person, or possessed by a cell in an individual person. For higher species, the genomic makeup includes DNA in the nucleus and in the organelles regardless of the number of chromosomes and the homoplasmic or heteroplasmic status of the mitochondrial or chloroplastic DNA. Practically, GENOME can be referred to at the molecular, cellular, individual, and species levels, which has various implications in biotechnological research and molecular diagnostics.

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