BACKGROUND: High-intensity Focused Ultrasound (HIFU) is a rapidly developing non-invasive treatment method for tumors in recent years. OBJECTIVE: The present study aimed to investigate the lesion and temperature effects of HIFU combined with different concentrations and volumes of ethanol on porcine liver. MATERIAL AND METHODS: In this experimental study, different concentrations and volumes of ethanol were injected into the focal area of porcine liver using B-mode ultrasound, and the focal temperature was monitored using a k-type needle thermocouple. The peak negative pressure and sound inten...