MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression

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成果类型：

期刊论文

作者：

Jia, Aijun;Wang, Yueling;Sun, Wenjin;Xiao, Bing;Wei, Yan;...

通讯作者：

Xiang, Xudong

作者机构：

[Jia, Aijun; Qiu, Lulu; Sun, Wenjin] Cent South Univ, Xiangya Hosp 2, Hunan Ctr Evidence Based Med, Dept Resp Med,Res Unit Resp Dis, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

[Zhang, Dongshan; Jia, Aijun; Xiang, Xudong; Xiao, Bing] Cent South Univ, Xiangya Hosp 2, Inst Emergency Med & Difficult Dis, Dept Emergency, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

[Wang, Yueling] Cent South Univ, Xiangya Hosp, Dept Anesthesiol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Wei, Yan] First Hosp Guangyuan City, Dept Resp Med, 490 Juguo Rd, Guangyuan 628000, Sichuan, Peoples R China.

[Mu, Lin] Changzhi Med Coll, Peace Hosp, Dept Resp Med, Changzhi 046000, Shanxi, Peoples R China.

通讯机构：

[Xiang, Xudong] C

Cent South Univ, Xiangya Hosp 2, Inst Emergency Med & Difficult Dis, Dept Emergency, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

语种：

英文

期刊：

Mediators of Inflammation

ISSN：

0962-9351

年：

2017

卷：

2017

页码：

6249685

DOI：

10.1155/2017/6249685

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370128]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [14JJ2028]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Th17 cells and IL-17 participate in airway neutrophil infiltration characteristics in the pathogenesis of severe asthma. Methyl-CpG binding domain protein 2 (MBD2) expression increased in CD4+ T cells in peripheral blood samples of asthma patients. However, little is known about that epigenetic regulation of MBD2 in both immunological pathogenesis of experimental severe asthma and CD4+ T cell differentiation. Here, we established a neutrophil-predominant severe asthma model, which was characterized by airway hyperresponsiveness (AHR), BALF neut...

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MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression

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