Apelin is an endogenous ligand of the apelin receptor（APJ）,a seven-transmembrane G protein-coupled receptor.Apelin and APJ exist in a variety of tissues,with special status in the heart,lung and tumors.Furthermore,many research shows that the apelin/APJ system exerts a broad range of activities that affect kidney systems.This review we summarize the role of apelin/APJ system on renal fibrosis,renal ischemia/reperfusion injury and diabetic nephropathy,polycystic kidney disease,hemodialysis.It was found that the level expression of apelin m RNA...
