期刊论文

Rang, W.-Q.

中文

中国药理学与毒理学杂志

1000-3002

2012

26

2

200-204

10.3867/j.issn.1000-3002.2012.02.014

(2010-203):湖南省卫生厅科研项目 (2011-KF4):湖南省衡阳市社会基金资助项目 (GLA102077):全国教育科学“十一五”规划2010年度教育部重点课题

本校为第一且通讯机构

目的探讨当归多糖(APS)对染铅大鼠的驱铅作用和对染铅所致贫血的治疗作用。方法4周龄SD幼鼠ip给予醋酸铅30 mg.kg~(-1)，隔天1次，连续7次，建立铅性贫血模型。建模第2天，ip给予APS15，30，60和120 mg.kg~(-1)，每天1次，共14 d。以给药当天为第1天，分别于给药前第7和14天剪尾取血，检测血铅(BPb)、血红蛋白(Hb)和红细胞(RBC)。第14天处死大鼠，股动脉取血，测定BPb、Hb、RBC、血细胞比容(Hct)、δ-氨基乙酰丙酸脱水酶(ALAD)活性和锌原卟啉(ZPP)浓度。采用石墨炉原子吸收光谱法测定全血血铅含量；采用氰化高铁法测定Hb含量；采用显微镜计数法计数RBC；采用血球分析仪测定Hct；采用二甲氨基苯甲...

OBJECTIVE: To investigate effect of Angelica polysaccharides (APS) on expelling lead and on anemia of young rats exposed to lead. METNODS: Four-week-old SD rats were ip given lead acetate 30 mg·kg-1 every other day, for 14 d. APS 15, 30, 60 and 120 mg·kg-1 were ig given on the 2nd day after model established, once daily. On the day before drug, the 7th and 14th days after drug, blood samples were collected and blood lead (BPb), hemoglobin (Hb) and red blood cells (RBC) were detected. On the 14th day after drug all the rats were sacrificed and...