Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer

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成果类型：

期刊论文

作者：

Huang, Wenjun;Zhu, Qingyun;Shi, Zhichao;Tu, Yao;Li, Qinyuan;...

通讯作者：

Hao, Yue;Chu, Bizhu;Jiang, YY

作者机构：

[Chu, Bizhu; Zheng, Wenwen; Hao, Yue; Hao, Y; Jiang, Yuyang; Huang, Wenjun; Jiang, YY; Zhu, Qingyun; Tu, Yao] Shenzhen Univ, Med Sch, Sch Pharm, Shenzhen 518055, Peoples R China.

[Zu, Xuyu; Zhu, Qingyun] Univ South China, Affiliated Hosp 1, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Shi, Zhichao; Jiang, Yuyang; Jiang, YY] Shenzhen Bay Lab, Inst Biomed Hlth Technol & Engn, Shenzhen 518132, Peoples R China.

[Li, Lulu; Jiang, Yuyang; Li, Qinyuan; Jiang, YY; Yuan, Zigao] Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China.

[Jiang, Yuyang; Jiang, YY] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China.

通讯机构：

[Chu, BZ; Hao, Y; Jiang, YY ] S

Shenzhen Univ, Med Sch, Sch Pharm, Shenzhen 518055, Peoples R China.

Shenzhen Bay Lab, Inst Biomed Hlth Technol & Engn, Shenzhen 518132, Peoples R China.

Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China.

Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China.

语种：

英文

期刊：

Cell Death Discovery

ISSN：

2058-7716

年：

2024

卷：

期：

页码：

143

DOI：

10.1038/s41420-024-01895-7

基金类别：

Funder(s): the Stable Support Project of Shenzhen Grant Reference Number: 20231120105309001 [20231120105309001]; Stable Support Project of Shenzhen [SKLCO202204]; State Key Laboratory of Chemical Oncogenomics Open Funding

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The existing conventional treatments for breast cancer, including immune checkpoint blockade, exhibit limited effects in some cancers, particularly triple-negative breast cancer. Epigenetic alterations, specifically DNMT and HDAC alterations, are implicated in breast cancer pathogenesis. We demonstrated that DNMTs and HDACs are overexpressed and positively correlated in breast cancer. The combination of DNMT and HDAC inhibitors has shown synergistic antitumour effects, and our previously designed dual DNMT and HDAC inhibitor (termed DNMT/HDACi) 15a potently inhibits breast cancer cell prolifer...

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Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer

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