Lipoprotein lipase: From gene to atherosclerosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yuan;He, Ping-Ping;Zhang, Da-Wei;Zheng, Xi-Long;Cayabyab, Fracisco S.;...

通讯作者：

Yin, Wei-Dong

作者机构：

[Li, Yuan; Tang, Chao-Ke; He, Ping-Ping; Yin, Wei-Dong] Univ South China, Life Sci Res Ctr, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Dept Biochem & Mol Biol,Libin Cardiovasc Inst Alb, Calgary, AB T2N 4N1, Canada.

[Cayabyab, Fracisco S.] Univ Saskatchewan, Coll Med, Dept Surg, Saskatoon, SK S7N 0W0, Canada.

通讯机构：

[Yin, Wei-Dong] U

Univ South China, Life Sci Res Ctr, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Inflammation;LPL;Lipid;Lipoprotein;Triglyceride

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2014

卷：

237

期：

页码：

597-608

DOI：

10.1016/j.atherosclerosis.2014.10.016

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270269, 81170278, 81370377, 81300158, 81300224]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China [2008-244]; construct program of the key discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

护理学院

摘要：

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal and heart muscle, as well as in macrophage and other tissues. After synthesized, it is secreted and translocated to the vascular lumen. LPL expression and activity are regulated by a variety of factors, such as transcription factors, interactive proteins and nutritional state through complicated mechanisms. LPL with different distributions may exert distinct functions and have diverse roles in human health and...

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