MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fang, Shiyi;Peng, Lanzhu;Zhang, Mengmin;Hou, Rentao;Deng, Xing;...

通讯作者：

Fang, Weiyi;Cheng, C;Liu, Z;Zhou, BX

作者机构：

[Xie, Yingying; Li, Xiaoning; Fang, Weiyi; Liu, Yiyi; Liu, Zhen; Cheng, Chao; Fang, Shiyi; Zhang, Mengmin; Hou, Rentao; Peng, Lanzhu] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Canc Ctr, Guangzhou, Peoples R China.

[Fang, Shiyi] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Deng, Xing] Naval Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai, Peoples R China.

[Liu, Zhen; Xin, Jianyang] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Sch Basic Med Sci, Key Lab Prot Modificat & Degradat, Guangzhou, Peoples R China.

[Peng, Lingrong] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Radiol, Guangzhou, Peoples R China.

通讯机构：

[Cheng, C ; Fang, WY] S

[Liu, Z ] G

[Zhou, BX ] P

Southern Med Univ, Integrated Hosp Tradit Chinese Med, Canc Ctr, Guangzhou, Guangdong, Peoples R China.

Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Lab Prot Modificat & Degradat, State Key Lab Resp Dis, Guangzhou, Peoples R China.

语种：

英文

关键词：

miR-2110;nasopharyngeal carcinoma;PTEN;tumor metastasis;ubiquitin

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2024

卷：

期：

页码：

3548-3562

DOI：

10.1002/tox.24197

基金类别：

National Natural Science Foundation of China#&#&#81872198 Basic and Applied Basic Research Foundation of Guangdong Province#&#&#2021A151 5012430#&#&#2020A1515110108 Natural Science Foundation of Guangdong Province#&#&#2019A1515110022

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

AbstractTumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma (NPC). MiR‐2110 was cloned and identified in Epstein–Barr virus (EBV)‐positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR‐2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR‐2110 can be regulated by cinobufotalin (CB) and participate in the inhibition of CB on NPC metastasis. Bioinformatics, RT‐PCR, and in situ hybridization were used to observe the expre...

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MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma

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