MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fang, Shiyi;Peng, Lanzhu;Zhang, Mengmin;Hou, Rentao;Deng, Xing;...

通讯作者：

Fang, Weiyi;Cheng, C;Liu, Z;Zhou, BX

作者机构：

[Xie, Yingying; Li, Xiaoning; Fang, Weiyi; Liu, Yiyi; Liu, Zhen; Cheng, Chao; Fang, Shiyi; Zhang, Mengmin; Hou, Rentao; Peng, Lanzhu] Southern Med Univ, Integrated Hosp Tradit Chinese Med, Canc Ctr, Guangzhou, Peoples R China.

[Fang, Shiyi] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Deng, Xing] Naval Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai, Peoples R China.

[Liu, Zhen; Xin, Jianyang] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Sch Basic Med Sci, Key Lab Prot Modificat & Degradat, Guangzhou, Peoples R China.

[Peng, Lingrong] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Radiol, Guangzhou, Peoples R China.

通讯机构：

[Cheng, C ; Fang, WY] S

[Liu, Z ] G

[Zhou, BX ] P

Southern Med Univ, Integrated Hosp Tradit Chinese Med, Canc Ctr, Guangzhou, Guangdong, Peoples R China.

Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Lab Prot Modificat & Degradat, State Key Lab Resp Dis, Guangzhou, Peoples R China.

语种：

英文

关键词：

PTEN;miR-2110;nasopharyngeal carcinoma;tumor metastasis;ubiquitin

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2024

DOI：

10.1002/tox.24197

基金类别：

Shenzhen Science and Technology Plan Projects

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma (NPC). MiR-2110 was cloned and identified in Epstein-Barr virus (EBV)-positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR-2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR-2110 can be regulated by cinobufotalin (CB) and participate in the inhibition of CB on NPC metastasis. Bioinformatics, RT-PCR, and in situ hybridization were used to observe the expression of miR-2110 in NPC tissues and cells. Scratch, Boyden, and...

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MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma

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