First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays

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成果类型：

期刊论文

作者：

Gao, Feng;Yang, Yiwei;Zhu, Hongyu;Wang, Jianxin;Xiao, Dexin;...

通讯作者：

Wu, D.

作者机构：

[Zhang, Yu; Feng, Gang; Du, Xiaobo; Gao, Feng; Dai, Tangzhi; Li, Jie; Lin, Binwei] Univ Elect Sci & Technol China, Mianyang Cent Hosp, Sch Med, Dept Oncol,Nucl Med Lab, Mianyang, Sichuan, Peoples R China.

[Yang, Yiwei] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang, Sichuan, Peoples R China.

[Zhu, Hongyu] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Radiat Oncol, State Key Lab Oncol South China, Guangzhou, Peoples R China.

[Li, Ming; Zhou, Kui; Shan, Lijun; Wang, Hanbin; Lao, Chenglong; Zhou, Zheng; Wang, Jianxin; Zhao, Jianheng; Li, Peng; Wu, Dai; Chen, Menxue; Xiao, Dexin; Yan, Longgang; Shen, Xuming; Lu, Yanhua] China Acad Engn Phys, Inst Appl Elect, Mianyang 621900, Sichuan, Peoples R China.

[Xie, Gang; Ke, Qi] Univ Elect Sci & Technol China, Mianyang Cent Hosp, Sch Med, Dept Pathol, Mianyang, Sichuan, Peoples R China.

通讯机构：

Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang, China

语种：

英文

关键词：

High-energy X-rays;FLASH radiotherapy;Conventional dose rate radiotherapy;FLASH effect

期刊：

Radiotherapy and Oncology

ISSN：

0167-8140

年：

2022

卷：

166

页码：

44-50

DOI：

10.1016/j.radonc.2021.11.004

基金类别：

National Natural Science Foundation of China [11975218, 11905210, 11805192, 12005211, 11605190]; Innovation Foundation of CAEP [CX2019036, CX2019037]

机构署名：

本校为其他机构

院系归属：

核科学技术学院

摘要：

Purpose: This study aimed to evaluate whether high-energy X-rays (HEXs) of the PARTER (platform for advanced radiotherapy research) platform built on CTFEL (Chengdu THz Free Electron Laser facility) can produce ultrahigh dose rate (FLASH) X-rays and trigger the FLASH effect. Materials and methods: EBT3 radiochromic film and fast current transformer (FCT) devices were used to measure absolute dose and pulsed beam current of HEXs. Subcutaneous tumor-bearing mice and healthy mice were treated with sham, FLASH, and conventional dose rate radiotherapy (CONV), respectively to observe the tumor contr...

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First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays

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