Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gao, Chuanyue;Zhang, Huan;Nie, Lulin;He, Kaiwu;Li, Peimao;...

通讯作者：

Xifei Yang

作者机构：

[Yang, Xifei; Gao, Chuanyue; Wang, Xingxing] Shanxi Med Univ, Sch Publ Hlth, Taiyuan, Peoples R China.

[Deng, Huiping; Liu, Jianjun; Yang, Xifei; Huang, Xinfeng; Gao, Chuanyue; Nie, Lulin; He, Kaiwu; Wang, Xingxing; Zhang, Huan] Shenzhen Ctr Dis Control & Prevent, Shenzhen Key Lab Modern Toxicol, Shenzhen Med Key Discipline Hlth Toxicol 2020 2024, Shenzhen, Peoples R China.

[Zhang, Huan] Univ South China, Sch Publ Hlth, Hengyang, Hunan, Peoples R China.

[Nie, Lulin] Jinan Univ Coll Pharm, Inst New Drug Res & Guangzhou, Key Lab Innovat Chem Drug Res Cardiocerebrovasc Di, Guangzhou 510632, Peoples R China.

[Li, Peimao] Shenzhen Prevent & Treatment Ctr Occupat Dis, Med Lab, Shenzhen, Peoples R China.

通讯机构：

[Xifei Yang] S

School of Public Health, Shanxi Medical University , Taiyuan , China<&wdkj&>Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention , Shenzhen , China

语种：

英文

关键词：

NAFLD;chrysin;inflammation;inflammasome;AMPK

期刊：

Journal of Pharmacy and Pharmacology

ISSN：

0022-3573

年：

2023

卷：

期：

页码：

1086-1099

DOI：

10.1093/jpp/rgad041

基金类别：

NSFC [82171583]; Key Basic Research Program of Shenzhen Science and Technology Innovation Commission [JCYJ20200109150717745 XY, JCYJ20200109144418639]; Shenzhen Key Medical Discipline Construction Fund [SZXK069]; Sanming Project of Medicine in Shenzhen [SZSM201611090]; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions [NYKFKT20190019]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

OBJECTIVES: We aimed to elucidate the therapeutic potential of Chrysin (CN) against the high-fat diet (HFD) induced non-alcoholic fatty liver disease (NAFLD) and its mechanism. METHODS: To assess the hypothesis, NAFLD was induced in C57BL/6 mice by feeding a high-fat diet for up to two months, followed by CN administration (for three months). Liver injury/toxicity, lipid deposition, inflammation and fibrosis were detected via molecular and biochemical analysis, including blood chemistry, immunoimaging and immunoblotting. Moreover, we performed proteomic analysis to illuminate Chrysin's therape...

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Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling

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