NO-1886 ameliorates glycogen metabolism in insulin-resistant HepG2 cells by GSK-3β signalling

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Zong-bao;Zeng, Huai-cai;Wei, Han-song;Yi, Guang-hui;Yu, Jian;...

通讯作者：

Yin, Wei-dong

作者机构：

[Zhang, Ya-li; Yin, Wei-dong; Wang, Zong-bao; Yi, Guang-hui; Wang, Yue-ting] Univ S China, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Yu, Jian; Wang, Zong-bao] Univ S China, Dept Lab Anim Sci, Hengyang 421001, Hunan, Peoples R China.

[Zeng, Huai-cai] Univ S China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

[Wei, Han-song] Ninghe Cty Hosp, Dept Lab Med, Tianjin, Peoples R China.

通讯机构：

[Yin, Wei-dong] U

Univ S China, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

glycogen synthesis;GSK-3β;insulin resistance;lipoprotein lipase;NO-1886

期刊：

Journal of Pharmacy and Pharmacology

ISSN：

0022-3573

年：

2012

卷：

期：

页码：

293-301

DOI：

10.1111/j.2042-7158.2011.01402.x

基金类别：

This work were supported by the science and technology project of Hunan Province, P.R.China. (2009(17), 2010TT1008) and aid program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

公共卫生学院

摘要：

Objectives The aim of the study was to elucidate the possible role and mechanism of NO-1886 (ibrolipim, a lipoprotein lipase activator) in ameliorating insulin resistance induced by high palmitate. Methods HepG2 cells were cultured in RPMI 1640 medium and were treated with palmitate to induce insulin resistance. Free fatty acids (FFAs), glucose, glycogen, cell viability and mRNA and protein levels were analysed separately. Key findings We found that HepG2 cells treated with 0.5 mm palmitate for 48 h led to a significant decrease of insulin-indu...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

NO-1886 ameliorates glycogen metabolism in insulin-resistant HepG2 cells by GSK-3β signalling

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问