Minimally Modified LDL-Induced Impairment of Endothelium-Dependent Relaxation in Small Mesenteric Arteries of Mice

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成果类型：

期刊论文

作者：

Chen, Gen;Wang, Jun-Jie;Xu, Cang-Bao;Cao, Lei;Lin, Jie;...

通讯作者：

Li, Jie

作者机构：

[Li, Jie; Chen, Gen; Qing, Xu-Ping] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Liu, Si-Yu; Li, Jie; Lin, Jie; Wang, Jun-Jie] Xiangnan Univ, Peoples Hosp Chenzhou 1, Chenzhou, Peoples R China.

[Xu, Cang-Bao] Xian Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Ischem Cardiovasc Dis, Xian, Peoples R China.

[Liu, En-Qi; Cao, Lei] Xi An Jiao Tong Univ, Sch Med, Dept Pharmacol, Xian, Peoples R China.

[Li, Jie] Xiangnan Univ, Peoples Hosp Chenzhou 1, Dept Pharm, Inpatient Dept, 3-F,Prov Youth 8th Ave, Chenzhou 423000, Hunan, Peoples R China.

通讯机构：

[Li, Jie] X

Xiangnan Univ, Peoples Hosp Chenzhou 1, Dept Pharm, Inpatient Dept, 3-F,Prov Youth 8th Ave, Chenzhou 423000, Hunan, Peoples R China.

语种：

英文

关键词：

Endothelium-dependent relaxation;Endothelium-derived hyperpolarizing factor;Minimally modified LDL;Mouse model;Nitric oxide;Resistance arteries

期刊：

JOURNAL OF VASCULAR RESEARCH

ISSN：

1018-1172

年：

2016

卷：

期：

1-2

页码：

58-71

DOI：

10.1159/000447011

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202535, 81470493]; Education Department of Hu'nan Province [15K114]; Science and Technology Office of Chenzhou [CZ2015008]; Hunan Province, China

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Minimally modified low-density lipoprotein (mmLDL) is a well-known risk factor for cardiovascular diseases. The present study was designed to investigate the role of mmLDL in the endothelium-dependent relaxation of mouse mesenteric arteries. A sensitive myograph system was employed to examine the endothelial function of mesenteric arteries. mRNA and protein expression levels were determined using real-time PCR and Western blotting, respectively. The ultra-microstructure of mesenteric vascular beds was investigated using a transmission electron microscope. The results showed that mmLDL signific...

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Minimally Modified LDL-Induced Impairment of Endothelium-Dependent Relaxation in Small Mesenteric Arteries of Mice

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