Immune evasion of Omicron variants JN.1, KP.2, and KP.3 to the polyclonal and monoclonal antibodies from COVID-19 convalescents and vaccine recipients

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Qian;Wu, Hairuo;Hu, Yabin;Zheng, Xingyu;Chang, Fangfang;...

通讯作者：

Li, YP;Qu, XW;Wu, X

作者机构：

[Chang, Fangfang; Tang, Fei; Qian, Jun; Liu, Yongchen; Wu, Qian; Huang, Bin; Li, Yuezhou; Chen, Keqiu; Wu, Hairuo; Xu, Juan; Li, Yi-Ping] Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med, Guangzhou 510080, Peoples R China.

[Chang, Fangfang; Tang, Fei; Qian, Jun; Liu, Yongchen; Wu, Qian; Huang, Bin; Li, Yuezhou; Chen, Keqiu; Wu, Hairuo; Xu, Juan; Li, Yi-Ping] Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Peoples R China.

[Zheng, Xingyu; Wang, You; Qu, Xiaowang; Hu, Yabin] Univ South China, Coll Basic Med Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Zheng, Xingyu; Wang, You; Qu, Xiaowang; Hu, Yabin] MOE Key Lab Rare Pediat Dis, Hengyang 421001, Peoples R China.

[Hu, Yabin] Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Hengyang Med Sch, Chenzhou 423000, Peoples R China.

通讯机构：

[Wu, X ; Qu, XW ] U

[Li, YP ] S

Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med, Guangzhou 510080, Peoples R China.

Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Peoples R China.

Univ South China, Coll Basic Med Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Broad cross-neutralizing activity;Inactivated vaccine;Monoclonal antibodies;Omicron variants;SARS-CoV-2

期刊：

Antiviral Research

ISSN：

0166-3542

年：

2025

卷：

235

页码：

106092

DOI：

10.1016/j.antiviral.2025.106092

基金类别：

CRediT authorship contribution statement Qian Wu: Writing – review & editing, Writing – original draft, Project administration, Methodology, Investigation, Data curation, Conceptualization. Hairuo Wu: Software, Methodology, Investigation, Data curation. Yabin Hu: Resources, Project administration, Data curation. Xingyu Zheng: Resources, Methodology. Fangfang Chang: Software, Methodology, Formal analysis. Yongchen Liu: Methodology, Data curation. Zhendong Pan: Methodology. Qijie Wang: acquisition. Fei Tang: Resources. Jun Qian:

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

The Omicron BA.2.86 subvariants, JN.1, KP.2, and KP.3, have become predominant globally, raising concerns about their immune evasion from vaccines and monoclonal antibody (mAb) treatments. These variants harbor more receptor-binding domain (RBD) mutations than the XBB and EG.5 sub-lineages, which are already known to compromise vaccine and therapeutic efficacy. We evaluated sera from individuals vaccinated with inactivated vaccines, with or without breakthrough infections, as well as COVID-19 convalescents. Our results showed a substantial decr...

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Immune evasion of Omicron variants JN.1, KP.2, and KP.3 to the polyclonal and monoclonal antibodies from COVID-19 convalescents and vaccine recipients

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