期刊论文

Chen, Linxi

英文

Clinical and Experimental Pharmacology and Physiology

0305-1870

2016

43

5

569-579

10.1111/1440-1681.12563

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 81470434]; Construct Program of the Key Discipline in Hunan Province; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department) [2014-405]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M560647, 2015T80875]; Hunan Provincial Science and Technology Project [2015RS4040]; Administration of Traditional Chinese Medicine of Hunan Province [201578]; Health and Family planning commission of Hunan Province [B2015-48]

本校为第一且通讯机构

Adipocytokines apelin peptide, the ligand of APJ (putative receptor related to the angiotensin receptor AT1), plays key roles in the pathogenesis and deterioration of cancer. In lung cancer, apelin elevating microvessel densities has been reported. Our previous research has characterized that apelin-13 promoted lung adenocarcinoma cell proliferation. However, the effect of apelin on metastasis in lung adenocarcinoma and the underlying mechanisms remain unclear. This study shows that apelin-13 induced human adenocarcinoma cell migration via the ...